Download manual de instalacion p4m900-m7 se. Neupro (rotigotine transdermal system) is a non-ergoline dopamine agonist used to treat early signs and symptoms of Parkinson's disease.The brand name Neupro is discontinued, but generic versions may be available.
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(Neupro ) is indicated for use as monotherapy in the treatment of early-stage Parkinson’s disease or, in the EU, as an adjunct to levodopa across all disease stages. Transdermal rotigotine is an effective and generally well tolerated addition to the armamentarium for the control of Parkinson’s disease, with the once-daily transdermal patch system offering several practical advantages and the possible benefits of avoiding pulsatile dopaminergic stimulation. Transdermal rotigotine was superior to placebo in patients with early-stage and advanced Parkinson’s disease, although noninferiority to the oral dopamine agonists ropinirole or pramipexole was not consistently demonstrated. Additional active comparator trials would be of interest. In the meantime, transdermal rotigotine offers a convenient new treatment option for patients with Parkinson’s disease. Rotigotine has agonist effects at all dopamine receptors in vitro, with the greatest Pharmacological affinity for, and activity at, the dopamine D receptor subtype. It also interacts to Properties some extent with α - and α -adrenergic receptors, serotonin 5-HT and 2B 2C 1A 5-HT receptors, and σ receptors, and to a minor extent with monoamine trans- porters. The beneficial effects of rotigotine in the treatment of Parkinson’s disease are thought to be mediated via activation of D , D and
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Neupro Rotigotine Transdermal Patch 2012 Best PictureJournal
CNS Drugs – Springer Journals
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